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Hebei Yunsheng Biological Technology Co., Ltd.

Contact Person: Ms. Eva Lee

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Phone: +86-771-2022627

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A kind of preparation method of methylsulfonamide
Edit:Hebei Yunsheng Biological Technology Co., Ltd.   PublicDate:2020-08-24

Methanesulfonamide has a wide range of uses, mainly used in pesticide intermediates, medicine and other fields. At the same time, it is also an important intermediate for the synthesis of high-efficiency herbicides. Since the product came out in the 1990s in our country, its output has increased. At the same time, it is also of great significance to study and improve the preparation method of methamphetamine.

In the domestic manufacturers of mesylsulfonamide, insoluble saccharin is used as raw material, concentrated sulfuric acid is used as catalyst, and it can be produced through multiple processes such as methanol esterification, reflux, methanol distillation, cooling, crystallization, separation, spin drying, and drying. to make. There are many production links in the whole process. The cost is also relatively high. In the new preparation method, we use methyl o-sulfonyl chlorobenzoate, an intermediate of insoluble saccharin, as the raw material. After amination with liquid ammonia, it is separated by a three-phase separator, spin-dried, and dried to produce crude methylsulfonamide. . We then use the process of dissolving, decolorizing, crystallization, filtering, drying, etc. to make the finished methylsulfonamide.

In the preparation of methyl sulfonamide, we often use the insoluble saccharin method and the sulfonyl chloride method. In fact, the initial raw material is methyl o-sulfonyl chloride benzoate. The difference is that the insoluble saccharin method uses methyl o-sulfonyl chloride benzoate. After amination, decolorization, pickling, spin-drying, and drying, the insoluble saccharin is obtained, and then esterified with methanol, using concentrated sulfuric acid as a catalyst. Reflux and other processes to prepare mesylsulfamide.

In the sulfonyl chloride method, methyl o-sulfonyl chloride benzoate is directly used as a raw material to prepare crude methanesulfonamide, and then through a series of processes to prepare methanesulfonamide. Compared with the preparation method of insoluble saccharin, this method saves many production process links.

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